MAPK8/9/10 抗体
This anti-MAPK8/9/10 antibody is a 兔 多克隆 antibody detecting MAPK8/9/10 in WB, IHC 和 IP. Suitable for 人.
Quick Overview for MAPK8/9/10 抗体 (ABIN7268630)
抗原
MAPK8/9/10
(Mitogen-Activated Protein Kinase 8/9/10 (MAPK8/9/10))
适用
人
宿主
兔
克隆类型
多克隆
标记
This MAPK8/9/10 antibody is un-conjugated
应用范围
Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
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原理
- JNK1/2/3 Rabbit pAb
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交叉反应
- 人, 小鼠, 大鼠
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产品特性
- Polyclonal Antibodies
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纯化方法
- Affinity purification
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免疫原
- Recombinant protein of human JNK1/2/3.
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亚型
- IgG
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anti-Mitogen-Activated Protein Kinase 8/9/10 (MAPK8/9/10) (pThr183), (pThr221), (pTyr185) antibody
MAPK8/9/10 适用: 人, 小鼠, 大鼠 WB, IF/ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB,1:500 - 1:2000,IHC,1:50 - 1:200,IP,1:50 - 1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- MAPK8/9/10 (Mitogen-Activated Protein Kinase 8/9/10 (MAPK8/9/10))
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别名
- MAPK8/MAPK9/MAPK10
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背景
- JNK belongs to MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. JNK is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation.JNK is expressed as ten different isoforms due to differential mRNA splicing. The predominant forms are JNK1,JNK2,and JNK3,MAPK8/MAPK9/MAPK10
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分子量
- 35kDa/44kDa/48kDa/27kDa/52kDa
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基因ID
- 5599, 5601, 5602
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UniProt
- P45983, P45984, P53779
抗原
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